Depending upon the primary tumor site, patients with neuroendocrine tumors frequently present with liver metastases. Liver resection is the only potentially curative treatment option. A complete resection of the hepatic tumor mass is feasible in only 20–57% of patients. The majority of resected patients will develop tumor recurrence within 5 years. Liver transplantation is justified in highly selected patients with nonresectable neuroendocrine liver metastases; however, the risk of posttransplant tumor recurrence is high. Management in centers of expertise should be strongly encouraged in order to enable a multidisciplinary approa

Chirurgische Therapie neuroendokriner.Lebermetastasen – Resektion, Transplantation

Tedeschi M;
2010-01-01

Abstract

Depending upon the primary tumor site, patients with neuroendocrine tumors frequently present with liver metastases. Liver resection is the only potentially curative treatment option. A complete resection of the hepatic tumor mass is feasible in only 20–57% of patients. The majority of resected patients will develop tumor recurrence within 5 years. Liver transplantation is justified in highly selected patients with nonresectable neuroendocrine liver metastases; however, the risk of posttransplant tumor recurrence is high. Management in centers of expertise should be strongly encouraged in order to enable a multidisciplinary approa
2010
In Abhängigkeit von der Primärtumorlokalisation treten Lebermetastasen bei einer Vielzahl von Patienten mit neuroendokrinen Tumoren auf. Eine Leberresektion stellt die einzige Therapieoption mit kurativer Intention dar. Eine komplette Resektion ist nur in 20–57% der Fälle möglich.Auch nach einer Resektion ist innerhalb von 5 Jahren mit einer hohen Rezidivrate zu rechnen. Palliative Leberresektionen sind nur im Einzellfall gerechtfertigt. Eine Lebertransplantation kann bei streng selektionierten Patienten mit nichtresektablen Lebermetastasen indiziert sein. Transplantierte Patienten weisen ein hohes Rezidivrisiko auf. Patienten mit neuroendokrinen Lebermetastasen sollten in Zentren mit interdisziplinärer Expertise behandelt werden.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12572/23151
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