Leptin, one of the major adipokines, is a pleiotropic hormone whose plasma levels rise with the increase in adipose tissue. Leptin has a dual role as a hormone and a cytokine. As a hormone, it plays a critical role in regulating appetite, growth, energy and bone metabolism. As a cytokine, leptin participates in the enhancement of some pro-inflammatory responses. Increasing leptin concentrations in serum in obese patients significantly contributes to the low-grade inflammatory state that makes those subjects more prone to develop insulin resistance, type 2 diabetes, cardiovascular and autoimmune diseases
Leptin: a marker of renal injury
Perrini Sebastio
2019-01-01
Abstract
Leptin, one of the major adipokines, is a pleiotropic hormone whose plasma levels rise with the increase in adipose tissue. Leptin has a dual role as a hormone and a cytokine. As a hormone, it plays a critical role in regulating appetite, growth, energy and bone metabolism. As a cytokine, leptin participates in the enhancement of some pro-inflammatory responses. Increasing leptin concentrations in serum in obese patients significantly contributes to the low-grade inflammatory state that makes those subjects more prone to develop insulin resistance, type 2 diabetes, cardiovascular and autoimmune diseasesFile in questo prodotto:
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