This paper aims to discuss the importance of Living Labs as an effective mechanism that can support the creation of dynamic innovation ecosystems and networks. The analysis of literature related to regional innovation and based on the Quadruple Helix framework, is integrated with exploratory research analysis of 20 cases of Italian Living Labs. The field study is realized through a web-based content analysis and questionnaires. The paper contributes to study how the Living Lab can constitute an effective mechanism supporting the creation of dynamic innovation ecosystems and networks, in the final aim to explore its relevance for setting regional strategies for smart growth, which valorize the internal and external knowledge assets. The paper provides important implications, both at research and policy levels, related with the knowledge-based innovation processes that could be activated at territorial level.
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