: The chick embryo chorioallantoic membrane (CAM) is a useful tool with which to study both angiogenesis and anti-angiogenesis in vivo. CAM vascular growth pattern - including the way through vessels fills the available space - can be quite easily described and quantified using image analysis procedures, in order to evaluate different parameters, including fractal dimension, lacunarity and non-fractal order-disorder parameters. In the present study, we further expanded this morphological description, by estimating an index expressing the degree of symmetry characterizing the CAM vascular tree structure in the course of the embryonic development. Moreover, a uniformity index was estimated quantitatively to characterize the space-filling features of the vessels, i.e. the degree of spatial uniformity of their distribution in the tissue.
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